Effects of atrophic changes in mucosa and endogenous gastrin (hypergastrinemia) on development of experimental gastric cancer and its growth in rats: a pilot study.
نویسندگان
چکیده
In the present experiment the influence of atrophic mucosa and resulting endogenous hypergastrinemia on the induction of gastric cancer by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was examined in male Donryu rats. All rats were fed MNNG in tap water for 6 months and were killed after more 5 months. The incidence of gastric cancer was 55% in rats with atrophic gastritis and hypergastrinemia, which is significantly higher than the incidence of 10 % observed in rats treated with MNNG alone. Gastric cancer was not found in any rats with atrophic gastritis without associating with hypergastrinemia. These data suggest that atrophic mucosa and resulting hypergastrinemia are important in development and growth of gastric cancer in rats. 213
منابع مشابه
Gastrin and Gastric Cancer
Gastric cancer is the third leading cause of cancer-related mortality worldwide. Despite progress in understanding its development, challenges with treatment remain. Gastrin, a peptide hormone, is trophic for normal gastrointestinal epithelium. Gastrin also has been shown to play an important role in the stimulation of growth of several gastrointestinal cancers including gastric cancer. We soug...
متن کاملThe Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia
The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P < 0.05), while the number of glands dra...
متن کاملThe cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated spasmolytic polypeptide-expressing metaplasia (SPEM). The hormone gastrin is important for normal function and maturation of the gastric oxyntic mucosa and hypergastrinemia might b...
متن کاملHelicobacter pylori induction of the gastrin promoter through GC-rich DNA elements.
BACKGROUND Helicobacter pylori (H. pylori) infection has been linked to the development of chronic gastritis, duodenal ulcer disease, and gastric cancer. Helicobacter pylori- infected patients and animal models develop hypergastrinemia, chronic gastritis, and gastric atrophy. Since gastrin is an important regulator of gastric acid secretion and cell growth, H. pylori regulation of this hormone ...
متن کاملTrophic Effects of Gastrin on Enterochromaffin-like (ecl) Cells and Its Tumor-promoting Role in Gastrointestinal Carcinogenesis
Gastrin is a central regulator of gastric acid, which is secreted by G cells that are mainly located in the antral part of the stomach and also in the duodenum. It stimulates acid secretion by inducing histamine release from the ECL cells (1). In addition to the stimulation of gastric acid secretion, gastrin acts as a potent cell-growth factor in a variety of normal and abnormal biological proc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Hiroshima journal of medical sciences
دوره 32 2 شماره
صفحات -
تاریخ انتشار 1983